5/25/2025
Last update
5/25/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
USERS' SCORE
Good
Based on 17 Reviews
8.4
Supplement Facts
Serving Size: 1 Caplet
Amount Per Serving
%DV
Organic ashwagandha powder (root)(0.2% Withanolides, 0.76 mg)
380 mg
*
Organic ashwagandha extract (root)(0.5% Withanolides, 1.4 mg)
280 mg
*
Organic ashwagandha supercriticalCO2 extract (root) (Withania somnifera) (8% Withanolides, 0.8 mg)
10 mg
*
Top Medical Research Studies
9
DHA shows promise for autoimmunity
We conducted a study to evaluate how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, can impact autoimmune disorders, specifically using an animal model of multiple sclerosis (MS). In this investigation, we worked with twenty-five Dark Agouti rats, dividing them into distinct groups. Some received DHA, while others served as controls, allowing for comparisons of its effectiveness on clinical symptoms and levels of oxidative stress.
Over the course of 51 days, DHA was administered via injections, with a daily 40 mg/kg dosage given five days a week. What we observed was quite encouraging. The DHA supplementation appeared to lead to a reduction in oxidative stress markers and showed improvements in clinical scores related to the disease. These results suggest that DHA has the potential to positively influence the progression of MS.
Furthermore, we believe this effect may be linked to DHA’s ability to activate Nrf2, an important antioxidant factor in our bodies. Overall, our findings indicate that DHA could be a beneficial treatment option for managing multiple sclerosis and possibly other autoimmune conditions.
Over the course of 51 days, DHA was administered via injections, with a daily 40 mg/kg dosage given five days a week. What we observed was quite encouraging. The DHA supplementation appeared to lead to a reduction in oxidative stress markers and showed improvements in clinical scores related to the disease. These results suggest that DHA has the potential to positively influence the progression of MS.
Furthermore, we believe this effect may be linked to DHA’s ability to activate Nrf2, an important antioxidant factor in our bodies. Overall, our findings indicate that DHA could be a beneficial treatment option for managing multiple sclerosis and possibly other autoimmune conditions.
Read More
9
We explored the effects of docosahexaenoic acid (DHA) on fibroblast-like synovial cells from patients with rheumatoid arthritis (RA). Our study demonstrated that DHA prompted cells to undergo apoptosis, or programmed cell death, particularly through a process dependent on caspase-8. This occurred in a dose-dependent manner, suggesting that higher amounts of DHA resulted in greater cell death.
Additionally, we observed that DHA was effective in reducing inflammation markers, such as MMP-9 and IL-1β, which are often heightened in autoimmune conditions like RA. The treatment also triggered important cellular responses, including the activation of endoplasmic reticulum (ER) stress markers like CHOP.
We discovered that lowering levels of CHOP or another protein called DR5 improved cell survival and diminished DHA-induced apoptosis. Importantly, our findings revealed that DHA led to an accumulation of reactive oxygen species (ROS), which are harmful byproducts that can damage cells. When we treated cells with an antioxidant, we found that it significantly reduced the expression of both CHOP and DR5, as well as the associated cell death.
Our results were consistent across both laboratory cell lines and primary synovial cells directly obtained from RA patients. This suggests that DHA may offer a new avenue for treatment by harnessing the body's cellular responses to combat the destructive processes of RA.
Additionally, we observed that DHA was effective in reducing inflammation markers, such as MMP-9 and IL-1β, which are often heightened in autoimmune conditions like RA. The treatment also triggered important cellular responses, including the activation of endoplasmic reticulum (ER) stress markers like CHOP.
We discovered that lowering levels of CHOP or another protein called DR5 improved cell survival and diminished DHA-induced apoptosis. Importantly, our findings revealed that DHA led to an accumulation of reactive oxygen species (ROS), which are harmful byproducts that can damage cells. When we treated cells with an antioxidant, we found that it significantly reduced the expression of both CHOP and DR5, as well as the associated cell death.
Our results were consistent across both laboratory cell lines and primary synovial cells directly obtained from RA patients. This suggests that DHA may offer a new avenue for treatment by harnessing the body's cellular responses to combat the destructive processes of RA.
Read More
9
We investigated how docosahexaenoic acid (DHA), a key fatty acid, influences autoimmune disorders like multiple sclerosis (MS). Our findings revealed that fatty acid metabolism, particularly through the enzyme stearoyl-CoA desaturase-1 (SCD1), plays a critical role in the differentiation of regulatory T cells (Tregs), which are important for maintaining immune balance.
The absence of SCD1 in T cells leads to increased hydrolysis of triglycerides and phosphatidylcholine. This process, facilitated by an enzyme known as adipose triglyceride lipase (ATGL), results in the release of DHA, which further enhances Treg differentiation. By activating the nuclear receptor known as peroxisome proliferator-activated receptor gamma, DHA helps promote a more robust Treg population, potentially reducing the risk of autoimmune reactions.
Our exploration underscores the significance of dietary fatty acids in regulating immune responses. By highlighting DHA's role in modulating Treg differentiation and its potential implications for treating autoimmune conditions, this study paves the way for future dietary interventions and therapeutic strategies aimed at controlling autoimmune disorders like MS.
The absence of SCD1 in T cells leads to increased hydrolysis of triglycerides and phosphatidylcholine. This process, facilitated by an enzyme known as adipose triglyceride lipase (ATGL), results in the release of DHA, which further enhances Treg differentiation. By activating the nuclear receptor known as peroxisome proliferator-activated receptor gamma, DHA helps promote a more robust Treg population, potentially reducing the risk of autoimmune reactions.
Our exploration underscores the significance of dietary fatty acids in regulating immune responses. By highlighting DHA's role in modulating Treg differentiation and its potential implications for treating autoimmune conditions, this study paves the way for future dietary interventions and therapeutic strategies aimed at controlling autoimmune disorders like MS.
Read More
Most Useful Reviews
10
Significant improvement
57 people found this helpful
Really effective! After ordering Ashwagandha Himalaya for the second time due to its benefits with my postpartum depression, my condition improved dramatically. It took about a week for tangible results—my appetite returned, panic attacks diminished, and I regained my energy and joy. I'm grateful there are no side effects.
Read More
9
Stress relief
31 people found this helpful
Excellent Ashwagandha! As a Multiple Sclerosis sufferer with Major Depressive Disorder and Generalised Anxiety, I've seen a significant reduction in stress and anxiety levels since taking this. I'm now emotionally balanced and far less stressed. Highly recommend it!
Read More
9
Calmed panic attacks
14 people found this helpful
My mother suffers from long-standing panic attacks and a spinal condition, so she sought calming remedies during medication breaks. She loved it so much that she ordered another can! She’s much calmer with reduced anxiety and tremors, prompting us to recommend it to others.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
- All Researches
9
DHA mediators reduce RA symptoms
We explored how lipid mediators derived from docosahexaenoic acid (DHA) impact rheumatoid arthritis (RA), an autoimmune disorder marked by inflammation and joint damage. In our investigation, we noted that a specific combination of lipid mediators produced from DHA, including 17S-monohydroxy docosahexaenoic acid, resolvin D5, and protectin DX, showed promise in reducing arthritis severity.
The study involved using collagen antibody-induced arthritis (CAIA) in mice and examining RANKL-induced osteoclast formation using RAW264.7 cells. We observed that these lipid mediators effectively lowered the expression of certain markers related to osteoclast formation. They also showed potential by suppressing inflammatory pathways within cells.
In addition to promising laboratory results, our findings indicated that mice treated with these lipid mediators exhibited significantly less swelling and inflammation in their paws. We noticed a decrease in inflammatory cytokines in their serum, which is crucial for managing autoimmune responses, while levels of an anti-inflammatory cytokine, IL-10, increased.
These findings suggest that the lipid mediators derived from DHA can alleviate joint inflammation and damage associated with rheumatoid arthritis, indicating their potential as a therapeutic option. Overall, our research highlights the positive effects of DHA-related lipid mediators on autoimmune disorders like RA.
The study involved using collagen antibody-induced arthritis (CAIA) in mice and examining RANKL-induced osteoclast formation using RAW264.7 cells. We observed that these lipid mediators effectively lowered the expression of certain markers related to osteoclast formation. They also showed potential by suppressing inflammatory pathways within cells.
In addition to promising laboratory results, our findings indicated that mice treated with these lipid mediators exhibited significantly less swelling and inflammation in their paws. We noticed a decrease in inflammatory cytokines in their serum, which is crucial for managing autoimmune responses, while levels of an anti-inflammatory cytokine, IL-10, increased.
These findings suggest that the lipid mediators derived from DHA can alleviate joint inflammation and damage associated with rheumatoid arthritis, indicating their potential as a therapeutic option. Overall, our research highlights the positive effects of DHA-related lipid mediators on autoimmune disorders like RA.
Read More
9
DHA shows promise for autoimmunity
We conducted a study to evaluate how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, can impact autoimmune disorders, specifically using an animal model of multiple sclerosis (MS). In this investigation, we worked with twenty-five Dark Agouti rats, dividing them into distinct groups. Some received DHA, while others served as controls, allowing for comparisons of its effectiveness on clinical symptoms and levels of oxidative stress.
Over the course of 51 days, DHA was administered via injections, with a daily 40 mg/kg dosage given five days a week. What we observed was quite encouraging. The DHA supplementation appeared to lead to a reduction in oxidative stress markers and showed improvements in clinical scores related to the disease. These results suggest that DHA has the potential to positively influence the progression of MS.
Furthermore, we believe this effect may be linked to DHA’s ability to activate Nrf2, an important antioxidant factor in our bodies. Overall, our findings indicate that DHA could be a beneficial treatment option for managing multiple sclerosis and possibly other autoimmune conditions.
Over the course of 51 days, DHA was administered via injections, with a daily 40 mg/kg dosage given five days a week. What we observed was quite encouraging. The DHA supplementation appeared to lead to a reduction in oxidative stress markers and showed improvements in clinical scores related to the disease. These results suggest that DHA has the potential to positively influence the progression of MS.
Furthermore, we believe this effect may be linked to DHA’s ability to activate Nrf2, an important antioxidant factor in our bodies. Overall, our findings indicate that DHA could be a beneficial treatment option for managing multiple sclerosis and possibly other autoimmune conditions.
Read More
9
We investigated how docosahexaenoic acid (DHA), a key fatty acid, influences autoimmune disorders like multiple sclerosis (MS). Our findings revealed that fatty acid metabolism, particularly through the enzyme stearoyl-CoA desaturase-1 (SCD1), plays a critical role in the differentiation of regulatory T cells (Tregs), which are important for maintaining immune balance.
The absence of SCD1 in T cells leads to increased hydrolysis of triglycerides and phosphatidylcholine. This process, facilitated by an enzyme known as adipose triglyceride lipase (ATGL), results in the release of DHA, which further enhances Treg differentiation. By activating the nuclear receptor known as peroxisome proliferator-activated receptor gamma, DHA helps promote a more robust Treg population, potentially reducing the risk of autoimmune reactions.
Our exploration underscores the significance of dietary fatty acids in regulating immune responses. By highlighting DHA's role in modulating Treg differentiation and its potential implications for treating autoimmune conditions, this study paves the way for future dietary interventions and therapeutic strategies aimed at controlling autoimmune disorders like MS.
The absence of SCD1 in T cells leads to increased hydrolysis of triglycerides and phosphatidylcholine. This process, facilitated by an enzyme known as adipose triglyceride lipase (ATGL), results in the release of DHA, which further enhances Treg differentiation. By activating the nuclear receptor known as peroxisome proliferator-activated receptor gamma, DHA helps promote a more robust Treg population, potentially reducing the risk of autoimmune reactions.
Our exploration underscores the significance of dietary fatty acids in regulating immune responses. By highlighting DHA's role in modulating Treg differentiation and its potential implications for treating autoimmune conditions, this study paves the way for future dietary interventions and therapeutic strategies aimed at controlling autoimmune disorders like MS.
Read More
9
We explored the effects of docosahexaenoic acid (DHA) on fibroblast-like synovial cells from patients with rheumatoid arthritis (RA). Our study demonstrated that DHA prompted cells to undergo apoptosis, or programmed cell death, particularly through a process dependent on caspase-8. This occurred in a dose-dependent manner, suggesting that higher amounts of DHA resulted in greater cell death.
Additionally, we observed that DHA was effective in reducing inflammation markers, such as MMP-9 and IL-1β, which are often heightened in autoimmune conditions like RA. The treatment also triggered important cellular responses, including the activation of endoplasmic reticulum (ER) stress markers like CHOP.
We discovered that lowering levels of CHOP or another protein called DR5 improved cell survival and diminished DHA-induced apoptosis. Importantly, our findings revealed that DHA led to an accumulation of reactive oxygen species (ROS), which are harmful byproducts that can damage cells. When we treated cells with an antioxidant, we found that it significantly reduced the expression of both CHOP and DR5, as well as the associated cell death.
Our results were consistent across both laboratory cell lines and primary synovial cells directly obtained from RA patients. This suggests that DHA may offer a new avenue for treatment by harnessing the body's cellular responses to combat the destructive processes of RA.
Additionally, we observed that DHA was effective in reducing inflammation markers, such as MMP-9 and IL-1β, which are often heightened in autoimmune conditions like RA. The treatment also triggered important cellular responses, including the activation of endoplasmic reticulum (ER) stress markers like CHOP.
We discovered that lowering levels of CHOP or another protein called DR5 improved cell survival and diminished DHA-induced apoptosis. Importantly, our findings revealed that DHA led to an accumulation of reactive oxygen species (ROS), which are harmful byproducts that can damage cells. When we treated cells with an antioxidant, we found that it significantly reduced the expression of both CHOP and DR5, as well as the associated cell death.
Our results were consistent across both laboratory cell lines and primary synovial cells directly obtained from RA patients. This suggests that DHA may offer a new avenue for treatment by harnessing the body's cellular responses to combat the destructive processes of RA.
Read More
9
We explored how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects autoimmune disorders like multiple sclerosis (MS). The study focused on an experimental model known as relapse-remitting experimental autoimmune encephalomyelitis (RR-EAE), which is commonly used to understand MS better.
Through our investigation, we found that DHA can be transformed into beneficial metabolites. One such metabolite, docosahexaenoyl ethanolamide (DHEA), was observed to lessen the polarization of immune cells, specifically naïve T-cells, towards proinflammatory types that can exacerbate autoimmune issues. This means that DHEA could help keep the immune response in check.
Moreover, we noticed that the levels of DHEA and related compounds changed as the disease progressed in the mice. Interestingly, when we administered DHEA daily to these mice, it delayed the onset of symptoms, slowed down relapses, and reduced the severity of clinical scores.
Overall, our findings suggest that DHEA and its metabolites may play a protective role in autoimmune disorders like MS and could serve as a promising nutritional complement to current treatments.
Through our investigation, we found that DHA can be transformed into beneficial metabolites. One such metabolite, docosahexaenoyl ethanolamide (DHEA), was observed to lessen the polarization of immune cells, specifically naïve T-cells, towards proinflammatory types that can exacerbate autoimmune issues. This means that DHEA could help keep the immune response in check.
Moreover, we noticed that the levels of DHEA and related compounds changed as the disease progressed in the mice. Interestingly, when we administered DHEA daily to these mice, it delayed the onset of symptoms, slowed down relapses, and reduced the severity of clinical scores.
Overall, our findings suggest that DHEA and its metabolites may play a protective role in autoimmune disorders like MS and could serve as a promising nutritional complement to current treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 17 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
10
Significant improvement
57 people found this helpful
Really effective! After ordering Ashwagandha Himalaya for the second time due to its benefits with my postpartum depression, my condition improved dramatically. It took about a week for tangible results—my appetite returned, panic attacks diminished, and I regained my energy and joy. I'm grateful there are no side effects.
Read More
9
Stress relief
31 people found this helpful
Excellent Ashwagandha! As a Multiple Sclerosis sufferer with Major Depressive Disorder and Generalised Anxiety, I've seen a significant reduction in stress and anxiety levels since taking this. I'm now emotionally balanced and far less stressed. Highly recommend it!
Read More
9
Calmed panic attacks
14 people found this helpful
My mother suffers from long-standing panic attacks and a spinal condition, so she sought calming remedies during medication breaks. She loved it so much that she ordered another can! She’s much calmer with reduced anxiety and tremors, prompting us to recommend it to others.
Read More
9
Less irritability
1 people found this helpful
I ordered high-quality ashwagandha to ease anxiety based on my grandmother’s advice. It’s organic and suitable for vegans. After two months, I’ve noticed a decrease in irritability, increased energy, and improved sleep. The specific taste and smell are tolerable. I plan to continue for another two months to manage my current life challenges.
Read More
7.5
Cumulative effects
29 people found this helpful
An effective remedy! For anti-stress rejuvenation, one tablet a day suffices, but don't expect immediate results. Ashwagandha acts cumulatively; I noticed effects after two weeks. It's calming yet energising, allowing me to accomplish tasks efficiently.
Read More
Frequently Asked Questions
10
Significant improvement
57 people found this helpful
Really effective! After ordering Ashwagandha Himalaya for the second time due to its benefits with my postpartum depression, my condition improved dramatically. It took about a week for tangible results—my appetite returned, panic attacks diminished, and I regained my energy and joy. I'm grateful there are no side effects.
7.5
Cumulative effects
29 people found this helpful
An effective remedy! For anti-stress rejuvenation, one tablet a day suffices, but don't expect immediate results. Ashwagandha acts cumulatively; I noticed effects after two weeks. It's calming yet energising, allowing me to accomplish tasks efficiently.
7.5
Positive effect noted
3 people found this helpful
The effect of ashwagandha is beautiful. To feel its effects, it needs to be taken for at least two months, but I noticed positive effects sooner with this brand.
9
Less irritability
1 people found this helpful
I ordered high-quality ashwagandha to ease anxiety based on my grandmother’s advice. It’s organic and suitable for vegans. After two months, I’ve noticed a decrease in irritability, increased energy, and improved sleep. The specific taste and smell are tolerable. I plan to continue for another two months to manage my current life challenges.
9
Stress relief
31 people found this helpful
Excellent Ashwagandha! As a Multiple Sclerosis sufferer with Major Depressive Disorder and Generalised Anxiety, I've seen a significant reduction in stress and anxiety levels since taking this. I'm now emotionally balanced and far less stressed. Highly recommend it!
2
No effect noted
I did not notice any change. I used it for over a month and did not experience any effect. I ordered it due to severe stress and anxiety, but one reason I stopped taking it is that I heard nutritionists warning of its dangers.
9
Enhanced energy levels
8 people found this helpful
Honest review, it's simply fantastic! This excellent adaptogen has transformed my prolonged fatigue into energised vitality. I feel as lively as if stung by a bee. My spirits are always high without overexcitement, just a pleasant cheerfulness. I take one tablet on an empty stomach and complement it with Cal + Mag from Now for nerve support. My sceptical husband is also pleased with the results. We are definitely ordering more!
6
Digestive support
2 people found this helpful
I take Ashwagandha along with two other Ayurvedic products. Over a month, I noticed improved digestion and relief from severe constipation. Overall, my health has started to improve, prompting me to reorder.
8
DHA benefits for lupus management
We delved into the effects of docosahexaenoic acid (DHA) on autoimmune disorders, focusing on its role in systemic lupus erythematosus (SLE). By examining data from 418 lupus patients, we aimed to understand how different types of fatty acids, such as omega-3 polyunsaturated fatty acids (PUFAs), impact disease activity, pain, and sleep disturbances.
Our findings highlighted that higher levels of DHA are linked with better outcomes for those living with SLE. Patients who had more long-chain omega-3 PUFAs, particularly DHA, reported less pain and improved overall disease management. Despite some participants showing low omega-3 levels, these results suggest there's significant room for improvement through dietary changes.
While we must conduct further studies to confirm these benefits, it’s clear that adjusting our intake of omega-3s could be a simple yet effective way to enhance the quality of life for individuals with autoimmune disorders like lupus. Precision nutrition strategies that include DHA supplementation have strong potential in optimizing treatment plans.
Our findings highlighted that higher levels of DHA are linked with better outcomes for those living with SLE. Patients who had more long-chain omega-3 PUFAs, particularly DHA, reported less pain and improved overall disease management. Despite some participants showing low omega-3 levels, these results suggest there's significant room for improvement through dietary changes.
While we must conduct further studies to confirm these benefits, it’s clear that adjusting our intake of omega-3s could be a simple yet effective way to enhance the quality of life for individuals with autoimmune disorders like lupus. Precision nutrition strategies that include DHA supplementation have strong potential in optimizing treatment plans.
9
DHA mediators reduce RA symptoms
We explored how lipid mediators derived from docosahexaenoic acid (DHA) impact rheumatoid arthritis (RA), an autoimmune disorder marked by inflammation and joint damage. In our investigation, we noted that a specific combination of lipid mediators produced from DHA, including 17S-monohydroxy docosahexaenoic acid, resolvin D5, and protectin DX, showed promise in reducing arthritis severity.
The study involved using collagen antibody-induced arthritis (CAIA) in mice and examining RANKL-induced osteoclast formation using RAW264.7 cells. We observed that these lipid mediators effectively lowered the expression of certain markers related to osteoclast formation. They also showed potential by suppressing inflammatory pathways within cells.
In addition to promising laboratory results, our findings indicated that mice treated with these lipid mediators exhibited significantly less swelling and inflammation in their paws. We noticed a decrease in inflammatory cytokines in their serum, which is crucial for managing autoimmune responses, while levels of an anti-inflammatory cytokine, IL-10, increased.
These findings suggest that the lipid mediators derived from DHA can alleviate joint inflammation and damage associated with rheumatoid arthritis, indicating their potential as a therapeutic option. Overall, our research highlights the positive effects of DHA-related lipid mediators on autoimmune disorders like RA.
The study involved using collagen antibody-induced arthritis (CAIA) in mice and examining RANKL-induced osteoclast formation using RAW264.7 cells. We observed that these lipid mediators effectively lowered the expression of certain markers related to osteoclast formation. They also showed potential by suppressing inflammatory pathways within cells.
In addition to promising laboratory results, our findings indicated that mice treated with these lipid mediators exhibited significantly less swelling and inflammation in their paws. We noticed a decrease in inflammatory cytokines in their serum, which is crucial for managing autoimmune responses, while levels of an anti-inflammatory cytokine, IL-10, increased.
These findings suggest that the lipid mediators derived from DHA can alleviate joint inflammation and damage associated with rheumatoid arthritis, indicating their potential as a therapeutic option. Overall, our research highlights the positive effects of DHA-related lipid mediators on autoimmune disorders like RA.
9
We investigated how docosahexaenoic acid (DHA), a key fatty acid, influences autoimmune disorders like multiple sclerosis (MS). Our findings revealed that fatty acid metabolism, particularly through the enzyme stearoyl-CoA desaturase-1 (SCD1), plays a critical role in the differentiation of regulatory T cells (Tregs), which are important for maintaining immune balance.
The absence of SCD1 in T cells leads to increased hydrolysis of triglycerides and phosphatidylcholine. This process, facilitated by an enzyme known as adipose triglyceride lipase (ATGL), results in the release of DHA, which further enhances Treg differentiation. By activating the nuclear receptor known as peroxisome proliferator-activated receptor gamma, DHA helps promote a more robust Treg population, potentially reducing the risk of autoimmune reactions.
Our exploration underscores the significance of dietary fatty acids in regulating immune responses. By highlighting DHA's role in modulating Treg differentiation and its potential implications for treating autoimmune conditions, this study paves the way for future dietary interventions and therapeutic strategies aimed at controlling autoimmune disorders like MS.
The absence of SCD1 in T cells leads to increased hydrolysis of triglycerides and phosphatidylcholine. This process, facilitated by an enzyme known as adipose triglyceride lipase (ATGL), results in the release of DHA, which further enhances Treg differentiation. By activating the nuclear receptor known as peroxisome proliferator-activated receptor gamma, DHA helps promote a more robust Treg population, potentially reducing the risk of autoimmune reactions.
Our exploration underscores the significance of dietary fatty acids in regulating immune responses. By highlighting DHA's role in modulating Treg differentiation and its potential implications for treating autoimmune conditions, this study paves the way for future dietary interventions and therapeutic strategies aimed at controlling autoimmune disorders like MS.
7
We explored the effects of a gluten-free diet supplemented with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on inflammation associated with Hashimoto's thyroiditis, an autoimmune disorder. In this study, 39 Caucasian women with Hashimoto's participated, and we analyzed how these dietary changes influenced long-chain fatty acid mediators.
Our findings suggest that the combination of a gluten-free diet, along with omega-3s like DHA and EPA, may help reduce the inflammatory state present in these patients. We observed significant increases in levels of anti-inflammatory mediators after the diet was implemented, indicating a potential benefit from these dietary changes.
However, it's important to note that this diet did not show any significant impact on anti-TPO and anti-TG antibody levels. Overall, while we recognized a reduction in inflammation associated with increased omega-3 intake, the specific effects of DHA alone remain challenging to isolate due to the combined dietary components.
Our findings suggest that the combination of a gluten-free diet, along with omega-3s like DHA and EPA, may help reduce the inflammatory state present in these patients. We observed significant increases in levels of anti-inflammatory mediators after the diet was implemented, indicating a potential benefit from these dietary changes.
However, it's important to note that this diet did not show any significant impact on anti-TPO and anti-TG antibody levels. Overall, while we recognized a reduction in inflammation associated with increased omega-3 intake, the specific effects of DHA alone remain challenging to isolate due to the combined dietary components.
7
DHA may aid autoimmune management
We looked into how docosahexaenoic acid (DHA), an omega-3 fatty acid, plays a role in managing autoimmune disorders. Our focus was on its anti-inflammatory properties and their potential to reduce disease activity in conditions like rheumatoid arthritis, lupus, and multiple sclerosis.
DHA is known for its beneficial effects on the immune system. We found that it can help inhibit the release of pro-inflammatory cytokines and reduce the activity of immune cells that contribute to autoimmunity. This means that integrating DHA into our diets might be a helpful strategy for those dealing with autoimmune diseases.
Additionally, research indicates that DHA supplementation can lead to improvements in symptom severity and overall health outcomes in autoimmune patients. With no definitive cures available for these conditions, the anti-inflammatory effects of DHA present an exciting avenue for future exploration.
It's important to emphasize that while the evidence suggests significant benefits, further randomized clinical trials are necessary to establish the best doses and confirm these findings. However, the current data certainly supports considering DHA as part of our approach to managing autoimmune disorders.
DHA is known for its beneficial effects on the immune system. We found that it can help inhibit the release of pro-inflammatory cytokines and reduce the activity of immune cells that contribute to autoimmunity. This means that integrating DHA into our diets might be a helpful strategy for those dealing with autoimmune diseases.
Additionally, research indicates that DHA supplementation can lead to improvements in symptom severity and overall health outcomes in autoimmune patients. With no definitive cures available for these conditions, the anti-inflammatory effects of DHA present an exciting avenue for future exploration.
It's important to emphasize that while the evidence suggests significant benefits, further randomized clinical trials are necessary to establish the best doses and confirm these findings. However, the current data certainly supports considering DHA as part of our approach to managing autoimmune disorders.
7
Docosahexaenoic acid shows promise
We explored the effects of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on autoimmune disorders, particularly focusing on its role in modifying inflammatory gene expression and disability in multiple sclerosis (MS).
This research incorporated 13 cohort studies involving 1,353 participants over varied periods. Our goal was to uncover whether higher intake of DHA could lead to better outcomes for MS as measured by the Expanded Disability Status Scale (EDSS) and changes in inflammatory markers.
Interestingly, we found that DHA consumption was linked to an improvement in EDSS scores, suggesting it may contribute positively to managing MS symptoms. Furthermore, our analysis showed that omega-3 fatty acids led to a decrease in pro-inflammatory markers such as TNF-α and IL-1, showcasing their potential anti-inflammatory effects.
However, it's important to note that not all omega-3 fatty acids were significantly tied to improvements in EDSS scores, which calls for further studies. Overall, while DHA appears promising in relation to autoimmune disorders, additional research is needed to solidify these findings.
This research incorporated 13 cohort studies involving 1,353 participants over varied periods. Our goal was to uncover whether higher intake of DHA could lead to better outcomes for MS as measured by the Expanded Disability Status Scale (EDSS) and changes in inflammatory markers.
Interestingly, we found that DHA consumption was linked to an improvement in EDSS scores, suggesting it may contribute positively to managing MS symptoms. Furthermore, our analysis showed that omega-3 fatty acids led to a decrease in pro-inflammatory markers such as TNF-α and IL-1, showcasing their potential anti-inflammatory effects.
However, it's important to note that not all omega-3 fatty acids were significantly tied to improvements in EDSS scores, which calls for further studies. Overall, while DHA appears promising in relation to autoimmune disorders, additional research is needed to solidify these findings.
References
- Gilley KN, Fenton JI, Zick SM, Li K, Wang L, et al. Serum fatty acid profiles in systemic lupus erythematosus and patient reported outcomes: The Michigan Lupus Epidemiology & Surveillance (MILES) Program. Front Immunol. 2024;15:1459297. 10.3389/fimmu.2024.1459297
- Szczuko M, Kacprzak J, Przybylska A, Szczuko U, Pobłocki J, et al. The Influence of an Anti-Inflammatory Gluten-Free Diet with EPA and DHA on the Involvement of Maresin and Resolvins in Hashimoto's Disease. Int J Mol Sci. 2024;25. 10.3390/ijms252111692
- Su Y, Han Y, Choi HS, Lee GY, Cho HW, et al. Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase attenuate RANKL-induced osteoclast differentiation and rheumatoid arthritis. Biomed Pharmacother. 2024;171:116153. 10.1016/j.biopha.2024.116153
- Wang M, Rajkumar S, Lai Y, Liu X, He J, et al. Tertiary lymphoid structures as local perpetuators of organ-specific immune injury: implication for lupus nephritis. Front Immunol. 2023;14:1204777. 10.3389/fimmu.2023.1204777
- Muñoz-Jurado A, Escribano BM, Galván A, Valdelvira ME, Caballero-Villarraso J, et al. Neuroprotective and antioxidant effects of docosahexaenoic acid (DHA) in an experimental model of multiple sclerosis. J Nutr Biochem. 2024;124:109497. 10.1016/j.jnutbio.2023.109497
- Poggioli R, Hirani K, Jogani VG, Ricordi C. Modulation of inflammation and immunity by omega-3 fatty acids: a possible role for prevention and to halt disease progression in autoimmune, viral, and age-related disorders. Eur Rev Med Pharmacol Sci. 2023;27:7380. 10.26355/eurrev_202308_33310
- Léger T, Brun A, Lanchais K, Rigaudière JP, Briat A, et al. Docosahexaenoic acid and etanercept could reduce functional and metabolic alterations during collagen-induced arthritis in rats without any synergistic effect. Life Sci. 2023;327:121826. 10.1016/j.lfs.2023.121826
- Grajchen E, Loix M, Baeten P, Côrte-Real BF, Hamad I, et al. Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity. Cell Mol Immunol. 2023;20:666. 10.1038/s41423-023-01011-2
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